AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A CIMBA study
Identifieur interne : 009040 ( Main/Exploration ); précédent : 009039; suivant : 009041AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A CIMBA study
Auteurs : Fergus J. Couch [États-Unis] ; Olga Sinilnikova [France] ; Robert A. Vierkant [États-Unis] ; V. Shane Pankratz [États-Unis] ; Zachary S. Fredericksen [États-Unis] ; Dominique Stoppa-Lyonnet [France] ; Isabelle Coupier [France] ; David Hughes [France] ; Agnès Hardouin [France] ; Pascaline Berthet [France] ; Susan Peock [Royaume-Uni] ; Margaret Cook [Royaume-Uni] ; Caroline Baynes [Royaume-Uni] ; Shirley Hodgson [Royaume-Uni] ; Patrick J. Morrison [Royaume-Uni] ; Mary E. Porteous [Royaume-Uni] ; Anna Jakubowska [Pologne] ; Jan Lubinski [Pologne] ; Jacek Gronwald [Pologne] ; Amanda B. Spurdle [Australie] ; Rita Schmutzler [Allemagne] ; Beatrix Versmold [Allemagne] ; Christoph Engel [Allemagne] ; Alfons Meindl [Allemagne] ; Christian Sutter [Allemagne] ; Jurgen Horst [Allemagne] ; Dieter Schaefer [Allemagne] ; Kenneth Offit [États-Unis] ; Tomas Kirchhoff [États-Unis] ; Irene L. Andrulis [Canada] ; Eduard Ilyushik [Canada] ; Gordon Glendon [Canada] ; Peter Devilee [Pays-Bas] ; Maaike P. G. Vreeswijk [Pays-Bas] ; Hans F. A. Vasen [Pays-Bas] ; Ake Borg [Suède] ; Katja Backenhorn [Suède] ; Jeffery P. Struewing [États-Unis] ; Mark H. Greene [États-Unis] ; Susan L. Neuhausen [États-Unis] ; Timothy R. Rebbeck ; Katherine Nathanson ; Susan Domchek ; Theresa Wagner [Autriche] ; Judy E. Garber [États-Unis] ; Csilla Szabo [États-Unis] ; Michal Zikan [République tchèque] ; Lenka Foretova [République tchèque] ; Janet E. Olson [États-Unis] ; Thomas A. Sellers [États-Unis] ; Noralane Lindor [États-Unis] ; Heli Nevanlinna [Finlande] ; Johanna Tommiska [Finlande] ; Kristiina Aittomaki [Finlande] ; Ute Hamann [Allemagne] ; Muhammad U. Rashid [Allemagne] ; Diana Torres [Allemagne] ; Jacques Simard [Canada] ; Francine Durocher [Canada] ; Frederic Guenard [Canada] ; Henry T. Lynch [États-Unis] ; Claudine Isaacs [États-Unis] ; Jeffrey Weitzel [États-Unis] ; Olufunmilayo I. Olopade [États-Unis] ; Steven Narod [Canada] ; Mary B. Daly [États-Unis] ; Andrew K. Godwin [États-Unis] ; Gail Tomlinson [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; Georgia Chenevix-Trench [Australie] ; Antonis C. Antoniouon [Royaume-Uni]Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2007.
Abstract
The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 co-operate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4935 BRCA1 and 2241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations were genotyped for F31I. Overall, homozygosity for the 31I allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined (HR = 0.91; 95% CI 0.77-1.06). Similarly, no significant association was seen in BRCA1 (HR = 0.90; 95% CI 0.75-1.08) or BRCA2 carriers (HR = 0.93; 95% CI 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.
Url:
DOI: 10.1158/1055-9965.EPI-07-0129
PubMed: 17627006
PubMed Central: 2775799
Affiliations:
- Allemagne, Australie, Autriche, Canada, Finlande, France, Pays-Bas, Pologne, Royaume-Uni, République tchèque, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Normandie, Bavière, Bohême centrale, Californie, District de Columbia, District de Haute-Bavière, District de Karlsruhe, District de Leipzig, Floride, Grand Londres, Hollande-Méridionale, Illinois, Maryland, Massachusetts, Minnesota, Moravie, Nebraska, Pennsylvanie, Rhône-Alpes, Région Normandie, Saxe (Land), Texas, Écosse, État de New York, Île-de-France
- Brno, Caen, Cambridge, Heidelberg, Leipzig, Leyde, Londres, Lyon, Munich, Paris, Prague, Édimbourg
- Université de Cambridge
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Le document en format XML
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Couch</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name><affiliation wicri:level="3"><nlm:aff id="A2">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. 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Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation wicri:level="3"><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre François Baclesse, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation wicri:level="3"><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre François Baclesse, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation wicri:level="4"><nlm:aff id="A8">Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation wicri:level="3"><nlm:aff id="A9">South West Thames Regional Genetics Service, St Georges Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>South West Thames Regional Genetics Service, St Georges Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation wicri:level="1"><nlm:aff id="A10">Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation wicri:level="3"><nlm:aff id="A11">South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation wicri:level="1"><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation wicri:level="3"><nlm:aff id="A16">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="3"><nlm:aff id="A17">Department of Gynaecology and Obstetrics, Technical University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, Technical University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation wicri:level="1"><nlm:aff id="A18">Institute of Human Genetics, University of Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Horst, Jurgen" sort="Horst, Jurgen" uniqKey="Horst J" first="Jurgen" last="Horst">Jurgen Horst</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Human Genetics, University of Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Muenster</wicri:regionArea><wicri:noRegion>University of Muenster</wicri:noRegion><wicri:noRegion>University of Muenster</wicri:noRegion><wicri:noRegion>University of Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Schaefer, Dieter" sort="Schaefer, Dieter" uniqKey="Schaefer D" first="Dieter" last="Schaefer">Dieter Schaefer</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Human Genetics, University of Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Frankfurt</wicri:regionArea><wicri:noRegion>University of Frankfurt</wicri:noRegion><wicri:noRegion>University of Frankfurt</wicri:noRegion><wicri:noRegion>University of Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="2"><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation wicri:level="2"><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Ilyushik, Eduard" sort="Ilyushik, Eduard" uniqKey="Ilyushik E" first="Eduard" last="Ilyushik">Eduard Ilyushik</name><affiliation wicri:level="1"><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Glendon, Gordon" sort="Glendon, Gordon" uniqKey="Glendon G" first="Gordon" last="Glendon">Gordon Glendon</name><affiliation wicri:level="1"><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><affiliation wicri:level="3"><nlm:aff id="A25">The Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The Foundation for the Detection of Hereditary Tumors, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Backenhorn, Katja" sort="Backenhorn, Katja" uniqKey="Backenhorn K" first="Katja" last="Backenhorn">Katja Backenhorn</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name><affiliation wicri:level="2"><nlm:aff id="A27">Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="2"><nlm:aff id="A28">Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="2"><nlm:aff id="A29">Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Domchek, Susan" sort="Domchek, Susan" uniqKey="Domchek S" first="Susan" last="Domchek">Susan Domchek</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name><affiliation wicri:level="1"><nlm:aff id="A31">Division of Senology, Medical University of Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Senology, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation wicri:level="2"><nlm:aff id="A32">Dana-Farber Cancer Institute, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name><affiliation wicri:level="3"><nlm:aff id="A33">Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="2"><nlm:aff id="A35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="2"><nlm:aff id="A36">Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Tommiska, Johanna" sort="Tommiska, Johanna" uniqKey="Tommiska J" first="Johanna" last="Tommiska">Johanna Tommiska</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Aittomaki, Kristiina" sort="Aittomaki, Kristiina" uniqKey="Aittomaki K" first="Kristiina" last="Aittomaki">Kristiina Aittomaki</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Rashid, Muhammad U" sort="Rashid, Muhammad U" uniqKey="Rashid M" first="Muhammad U." last="Rashid">Muhammad U. Rashid</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Durocher, Francine" sort="Durocher, Francine" uniqKey="Durocher F" first="Francine" last="Durocher">Francine Durocher</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Guenard, Frederic" sort="Guenard, Frederic" uniqKey="Guenard F" first="Frederic" last="Guenard">Frederic Guenard</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation wicri:level="2"><nlm:aff id="A41">Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nebraska</region></placeName><wicri:cityArea>Department of Preventive Medicine and Public Health, Creighton University, Omaha</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A42">Lombardi Cancer Center, Georgetown University, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Lombardi Cancer Center, Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation wicri:level="2"><nlm:aff id="A43">City of Hope Cancer Center, Duarte, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>City of Hope Cancer Center, Duarte</wicri:cityArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="2"><nlm:aff id="A44">University of Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><affiliation wicri:level="1"><nlm:aff id="A45">Centre for Research in Women's Health, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research in Women's Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="2"><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="2"><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><affiliation wicri:level="2"><nlm:aff id="A47">University of Texas Southwestern Medical Center at Dallas, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>University of Texas Southwestern Medical Center at Dallas, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Antoniouon, Antonis C" sort="Antoniouon, Antonis C" uniqKey="Antoniouon A" first="Antonis C." last="Antoniouon">Antonis C. Antoniouon</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17627006</idno><idno type="pmc">2775799</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775799</idno><idno type="RBID">PMC:2775799</idno><idno type="doi">10.1158/1055-9965.EPI-07-0129</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001473</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001473</idno><idno type="wicri:Area/Pmc/Curation">001333</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001333</idno><idno type="wicri:Area/Pmc/Checkpoint">002B67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002B67</idno><idno type="wicri:Area/Ncbi/Merge">000283</idno><idno type="wicri:Area/Ncbi/Curation">000283</idno><idno type="wicri:Area/Ncbi/Checkpoint">000283</idno><idno type="wicri:Area/Main/Merge">009A13</idno><idno type="wicri:Area/Main/Curation">009040</idno><idno type="wicri:Area/Main/Exploration">009040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>AURKA</italic> F31I Polymorphism and Breast Cancer Risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> Mutation Carriers: A CIMBA study</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name><affiliation wicri:level="3"><nlm:aff id="A2">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="3"><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation wicri:level="3"><nlm:aff id="A4">INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U509, Service de Génétique Oncologique, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hughes, David" sort="Hughes, David" uniqKey="Hughes D" first="David" last="Hughes">David Hughes</name><affiliation wicri:level="3"><nlm:aff id="A5">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation wicri:level="3"><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre François Baclesse, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation wicri:level="3"><nlm:aff id="A6">Centre François Baclesse, Caen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre François Baclesse, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><affiliation wicri:level="4"><nlm:aff id="A8">Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research U.K., Human Cancer Genetics Group, Department of Oncology, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation wicri:level="3"><nlm:aff id="A9">South West Thames Regional Genetics Service, St Georges Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>South West Thames Regional Genetics Service, St Georges Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation wicri:level="1"><nlm:aff id="A10">Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northern Ireland Regional Genetics Centre, Cancer Genetics Service, Belfast City Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation wicri:level="3"><nlm:aff id="A11">South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>South East of Scotland Clinical Genetics Service, Western General Hospital, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation wicri:level="1"><nlm:aff id="A15">Division of Molecular Gyneco-Oncology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Gyneco-Oncology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation wicri:level="3"><nlm:aff id="A16">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="3"><nlm:aff id="A17">Department of Gynaecology and Obstetrics, Technical University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, Technical University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation wicri:level="1"><nlm:aff id="A18">Institute of Human Genetics, University of Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Horst, Jurgen" sort="Horst, Jurgen" uniqKey="Horst J" first="Jurgen" last="Horst">Jurgen Horst</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Human Genetics, University of Muenster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Muenster</wicri:regionArea><wicri:noRegion>University of Muenster</wicri:noRegion><wicri:noRegion>University of Muenster</wicri:noRegion><wicri:noRegion>University of Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Schaefer, Dieter" sort="Schaefer, Dieter" uniqKey="Schaefer D" first="Dieter" last="Schaefer">Dieter Schaefer</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Human Genetics, University of Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Frankfurt</wicri:regionArea><wicri:noRegion>University of Frankfurt</wicri:noRegion><wicri:noRegion>University of Frankfurt</wicri:noRegion><wicri:noRegion>University of Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation wicri:level="2"><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation wicri:level="2"><nlm:aff id="A21">Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Ilyushik, Eduard" sort="Ilyushik, Eduard" uniqKey="Ilyushik E" first="Eduard" last="Ilyushik">Eduard Ilyushik</name><affiliation wicri:level="1"><nlm:aff id="A22">Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Glendon, Gordon" sort="Glendon, Gordon" uniqKey="Glendon G" first="Gordon" last="Glendon">Gordon Glendon</name><affiliation wicri:level="1"><nlm:aff id="A23">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name><affiliation wicri:level="3"><nlm:aff id="A24">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><affiliation wicri:level="3"><nlm:aff id="A25">The Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>The Foundation for the Detection of Hereditary Tumors, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Backenhorn, Katja" sort="Backenhorn, Katja" uniqKey="Backenhorn K" first="Katja" last="Backenhorn">Katja Backenhorn</name><affiliation wicri:level="1"><nlm:aff id="A26">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology, Lund University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name><affiliation wicri:level="2"><nlm:aff id="A27">Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="2"><nlm:aff id="A28">Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation wicri:level="2"><nlm:aff id="A29">Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Domchek, Susan" sort="Domchek, Susan" uniqKey="Domchek S" first="Susan" last="Domchek">Susan Domchek</name><affiliation><nlm:aff id="A30">Abramson Cancer Center, University of Pennsylvania School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Pennsylvania School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name><affiliation wicri:level="1"><nlm:aff id="A31">Division of Senology, Medical University of Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Senology, Medical University of Vienna</wicri:regionArea><wicri:noRegion>Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation wicri:level="2"><nlm:aff id="A32">Dana-Farber Cancer Institute, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name><affiliation wicri:level="3"><nlm:aff id="A33">Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="2"><nlm:aff id="A35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation wicri:level="2"><nlm:aff id="A36">Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Tommiska, Johanna" sort="Tommiska, Johanna" uniqKey="Tommiska J" first="Johanna" last="Tommiska">Johanna Tommiska</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology (JT, HN), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Aittomaki, Kristiina" sort="Aittomaki, Kristiina" uniqKey="Aittomaki K" first="Kristiina" last="Aittomaki">Kristiina Aittomaki</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Genetics (KA), Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Rashid, Muhammad U" sort="Rashid, Muhammad U" uniqKey="Rashid M" first="Muhammad U." last="Rashid">Muhammad U. Rashid</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation wicri:level="3"><nlm:aff id="A39">Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Krebsforschungszentrum (DKFZ) Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Durocher, Francine" sort="Durocher, Francine" uniqKey="Durocher F" first="Francine" last="Durocher">Francine Durocher</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Guenard, Frederic" sort="Guenard, Frederic" uniqKey="Guenard F" first="Frederic" last="Guenard">Frederic Guenard</name><affiliation wicri:level="1"><nlm:aff id="A40">Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Centre, Centre Hospitalier Universitaire de Québec and Laval University, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation wicri:level="2"><nlm:aff id="A41">Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nebraska</region></placeName><wicri:cityArea>Department of Preventive Medicine and Public Health, Creighton University, Omaha</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A42">Lombardi Cancer Center, Georgetown University, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Lombardi Cancer Center, Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation wicri:level="2"><nlm:aff id="A43">City of Hope Cancer Center, Duarte, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>City of Hope Cancer Center, Duarte</wicri:cityArea></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation wicri:level="2"><nlm:aff id="A44">University of Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><affiliation wicri:level="1"><nlm:aff id="A45">Centre for Research in Women's Health, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research in Women's Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation wicri:level="2"><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation wicri:level="2"><nlm:aff id="A46">Fox Chase Cancer Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><affiliation wicri:level="2"><nlm:aff id="A47">University of Texas Southwestern Medical Center at Dallas, Dallas, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>University of Texas Southwestern Medical Center at Dallas, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="A13">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Antoniouon, Antonis C" sort="Antoniouon, Antonis C" uniqKey="Antoniouon A" first="Antonis C." last="Antoniouon">Antonis C. Antoniouon</name><affiliation wicri:level="4"><nlm:aff id="A7">Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 co-operate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4935 BRCA1 and 2241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations were genotyped for F31I. Overall, homozygosity for the 31I allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined (HR = 0.91; 95% CI 0.77-1.06). Similarly, no significant association was seen in BRCA1 (HR = 0.90; 95% CI 0.75-1.08) or BRCA2 carriers (HR = 0.93; 95% CI 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Finlande</li><li>France</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Basse-Normandie</li><li>Bavière</li><li>Bohême centrale</li><li>Californie</li><li>District de Columbia</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>District de Leipzig</li><li>Floride</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Moravie</li><li>Nebraska</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Région Normandie</li><li>Saxe (Land)</li><li>Texas</li><li>Écosse</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Brno</li><li>Caen</li><li>Cambridge</li><li>Heidelberg</li><li>Leipzig</li><li>Leyde</li><li>Londres</li><li>Lyon</li><li>Munich</li><li>Paris</li><li>Prague</li><li>Édimbourg</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Domchek, Susan" sort="Domchek, Susan" uniqKey="Domchek S" first="Susan" last="Domchek">Susan Domchek</name><name sortKey="Nathanson, Katherine" sort="Nathanson, Katherine" uniqKey="Nathanson K" first="Katherine" last="Nathanson">Katherine Nathanson</name><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name></noCountry><country name="États-Unis"><region name="Minnesota"><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></region><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name><name sortKey="Szabo, Csilla" sort="Szabo, Csilla" uniqKey="Szabo C" first="Csilla" last="Szabo">Csilla Szabo</name><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Sinilnikova, Olga" sort="Sinilnikova, Olga" uniqKey="Sinilnikova O" first="Olga" last="Sinilnikova">Olga Sinilnikova</name></region><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><name sortKey="Hughes, David" sort="Hughes, David" uniqKey="Hughes D" first="David" last="Hughes">David Hughes</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name></region><name sortKey="Antoniouon, Antonis C" sort="Antoniouon, Antonis C" uniqKey="Antoniouon A" first="Antonis C." last="Antoniouon">Antonis C. Antoniouon</name><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name></country><country name="Pologne"><noRegion><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name></noRegion><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></country><country name="Australie"><noRegion><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name></noRegion><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></country><country name="Allemagne"><noRegion><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name></noRegion><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><name sortKey="Horst, Jurgen" sort="Horst, Jurgen" uniqKey="Horst J" first="Jurgen" last="Horst">Jurgen Horst</name><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><name sortKey="Rashid, Muhammad U" sort="Rashid, Muhammad U" uniqKey="Rashid M" first="Muhammad U." last="Rashid">Muhammad U. Rashid</name><name sortKey="Schaefer, Dieter" sort="Schaefer, Dieter" uniqKey="Schaefer D" first="Dieter" last="Schaefer">Dieter Schaefer</name><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name></country><country name="Canada"><noRegion><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></noRegion><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><name sortKey="Durocher, Francine" sort="Durocher, Francine" uniqKey="Durocher F" first="Francine" last="Durocher">Francine Durocher</name><name sortKey="Glendon, Gordon" sort="Glendon, Gordon" uniqKey="Glendon G" first="Gordon" last="Glendon">Gordon Glendon</name><name sortKey="Guenard, Frederic" sort="Guenard, Frederic" uniqKey="Guenard F" first="Frederic" last="Guenard">Frederic Guenard</name><name sortKey="Ilyushik, Eduard" sort="Ilyushik, Eduard" uniqKey="Ilyushik E" first="Eduard" last="Ilyushik">Eduard Ilyushik</name><name sortKey="Narod, Steven" sort="Narod, Steven" uniqKey="Narod S" first="Steven" last="Narod">Steven Narod</name><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name></region><name sortKey="Vasen, Hans F A" sort="Vasen, Hans F A" uniqKey="Vasen H" first="Hans F. A." last="Vasen">Hans F. A. Vasen</name><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name></country><country name="Suède"><noRegion><name sortKey="Borg, Ake" sort="Borg, Ake" uniqKey="Borg A" first="Ake" last="Borg">Ake Borg</name></noRegion><name sortKey="Backenhorn, Katja" sort="Backenhorn, Katja" uniqKey="Backenhorn K" first="Katja" last="Backenhorn">Katja Backenhorn</name></country><country name="Autriche"><noRegion><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name></region><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name></country><country name="Finlande"><noRegion><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name></noRegion><name sortKey="Aittomaki, Kristiina" sort="Aittomaki, Kristiina" uniqKey="Aittomaki K" first="Kristiina" last="Aittomaki">Kristiina Aittomaki</name><name sortKey="Tommiska, Johanna" sort="Tommiska, Johanna" uniqKey="Tommiska J" first="Johanna" last="Tommiska">Johanna Tommiska</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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